Spectroscopic and Characterization of Medical and Physical Applications of Metal Complexes of Schiff bases in nano-sized Shape: Mg(II), Ca(II) and Ba(II) Schiff base Complexes

Mg(II), Ca(II) and Ba(II) metal chelates with formulas, [Mg(HL)2(Cl)2].6H2O, [Ca(HL)2(Cl)2].2H2O and [Ba(HL)2(H2O)2].Cl2.2H2O thatHL is the Schiff base moiety formed from condensation of 2-thiophenecarboxaldehyde with 2-chlorophenyl hydrazine have been prepared and characterized by elemental analysis and spectroscopic measurements (infrared and 1 H-NMR). Elemental analysis of the complexes suggests the stoichiometry is 1:2 (metalligand). Infrared spectra of the complexes agree with the coordination to the central metal atom through the nitrogen of the 2-chlorophenyl hydrazine(–Ph–NH-) group and the sulfur atom of the thiophene ring. Biological properties of prepared compounds were studied included antimicrobial activity and cytotoxicity. A potent antimicrobial activity evaluated by disc inhibition zone and variety degree of activity recorded against gram-positive; gram-negative and fungal strains. Cytotoxicity against two cell lines; MCF-7 and HePG-2 were evaluated and IC50 values were calculated. The [Ba(HL)2(H2O)2].Cl2.2H2O and [Mg(HL)2(Cl)2].6H2O had the highest antitumor effect with IC50 values; 32.6 and 30.4μg/ml for MCF-7 cell line and 37.5 ; 39.5 μg/ml for HePG-2 cell line. .